Standard Treatment Chemotherapy is given before surgery or radiotherapy in an attempt to shrink tumors and make them more treatable. This should be considered for each of the sites below except inverting papilloma and midline lethal granuloma.
• Maxillary sinus: If the tumor is extensive, surgery may not be appropriate and radiotherapy is used. Sinus
drainage must be established first.
• Ethmoid sinus: Radiotherapy or extensive surgery with pre- or postoperative radiotherapy.
• Sphenoid sinus: Same as nasopharyngeal cancers.
• Nasal cavity: Surgery or radiotherapy alone or combined.
• Inverting papilloma: Surgery. Radiotherapy or radical surgery may eventually be necessary.
• Melanomas and sarcomas: Surgery if possible, but radiation and chemotherapy should be considered.
• Midline granuloma: Radiotherapy.
• Nasal vestibule: Radiation if possible and surgery if unsuccessful.
Clinical trials for maxillary sinus, ethmoid sinus and nasal cavity tumors are evaluating chemotherapy combinations in addition to surgery or radiotherapy.
